Author

Jason J. Colasanti

Washington University in St. LouisORCID 0000-0002-7151-0011Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrea C. SantefordiD· 2 shared Joseph B. LiniD· 2 shared Rajendra S. ApteiD· 2 shared Ryo TeraoiD· 2 shared Tae Jun LeeiD· 2 shared Brian S. SohniD· 1 shared Charles W. PfeiferiD· 1 shared Daniel Du· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Andrea C. SantefordORCID

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2 papers

Recent·Most cited

MicroRNA-34a suppresses KLF2 to promote pathological angiogenesis through the CXCR4/CXCL12 pathway in age-related macular degeneration

Jason J. Colasanti, Andrea C. Santeford, Joseph B. Lin, Ryo Terao, Tae Jun Lee, Rajendra S. Apte

This study identifies miR-34a's role in promoting pathological angiogenesis in AMD by suppressing KLF2 and upregulating CXCR4/CXCL12.

Proceedings of the National Academy of Sciences · Aug 12, 2026Peer-reviewedMolecular Biology

Macrophage immunosenescence prolongs intraocular inflammation in aged mice via impaired induction of regulatory T cells

Taku Yamamoto, Keitaro Hase, Joseph B. Lin, Shinobu Yamaguchi, Norihiko Misawa, Jiayi Li, Kenta Kato, Ryo Terao, Brian S. Sohn, Daniel Du, Mitsukuni Yoshida, Charles W. Pfeifer, Tae Jun Lee, Jason J. Colasanti, Andrea C. Santeford, , Rajendra S. Apte

This study shows that aging impairs macrophage-induced regulatory T cells in mice, leading to chronic uveitis by linking immunosenescence to persistent inflammation.

bioRxiv · Jan 20, 2026 · PreprintImmunology