Author

Joseph B. Lin

Washington University in St. LouisORCID 0000-0001-6667-9018Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Rajendra S. ApteiD· 3 shared Tae Jun LeeiD· 3 shared Andrea C. SantefordiD· 2 shared Jason J. ColasantiiD· 2 shared Ryo TeraoiD· 2 shared Aaron DiAntonioiD· 1 shared Abdoulaye Sène· 1 shared Brian S. SohniD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Rajendra S. ApteORCID

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3 papers

Recent·Most cited

Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedAug 12, 2026

MicroRNA-34a suppresses KLF2 to promote pathological angiogenesis through the CXCR4/CXCL12 pathway in age-related macular degeneration

Jason J. Colasanti, Andrea C. Santeford, Joseph B. Lin…·Rajendra S. Apte

This study identifies miR-34a's role in promoting pathological angiogenesis in AMD by suppressing KLF2 and upregulating CXCR4/CXCL12.

1 citation

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ImmunologybioRxivPreprintJan 20, 2026

Macrophage immunosenescence prolongs intraocular inflammation in aged mice via impaired induction of regulatory T cells

Taku Yamamoto, Keitaro Hase, Joseph B. Lin…·Rajendra S. Apte

This study shows that aging impairs macrophage-induced regulatory T cells in mice, leading to chronic uveitis by linking immunosenescence to persistent inflammation.

1 citation

mousebulk RNA-seq

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NeuroscienceeLifePeer-reviewedOct 27, 2020

SARM1 depletion rescues NMNAT1 dependent photoreceptor cell death and retinal degeneration.

Yo Sasaki, Hiroki Kakita, Shunsuke Kubota…·Jeffrey Milbrandt

This study shows that SARM1 depletion prevents NMNAT1-dependent photoreceptor death and retinal degeneration in mice, identifying SARM1 as a therapeutic target for retinopathies.

77 citationstop 4%

mouseexperimental assay

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