Author

Daniel E. Cooper

Duke Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:metabolomics· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

David G. KirschiD· 2 shared Jason W. LocasaleiD· 2 shared Ahmad A. Cluntun· 1 shared Juan Liu· 1 shared Kathryn E. Wellen· 1 shared Marc O. Warmoes· 1 shared Michael A. Reid· 1 shared Shiyu LiuiD· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersSystems Biology

David G. KirschORCID

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2 papers

Recent·Most cited

Quantitative analysis of the physiological contributions of glucose to the TCA cycle

Shiyu Liu, Ziwei Dai, Daniel E. Cooper, David G. Kirsch, Jason W. Locasale

The paper quantitatively analyzes the physiological contributions of glucose to the TCA cycle using isotope-labeling data and metabolic flux analysis, showing glucose is the major nutrient source across tissues and conditions.

Cell Metabolism · Sep 21, 2020Peer-reviewedSystems Biology

Acetate is generated de novo from glucose metabolism in mammals and is coupled to central carbon metabolism

Xiaojing Liu, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Kathryn E. Wellen, David G. Kirsch, Jason W. Locasale

The paper shows that glucose metabolism generates acetate through two mechanisms and demonstrates its role in maintaining Ac-CoA pools and cell proliferation under specific metabolic conditions.

bioRxiv · Feb 4, 2018 · PreprintBiochemistry