Xiaojing Liu

Regulation of urea cycle by reversible high stoichiometry lysine succinylation

This study identifies high stoichiometry lysine succinylation sites in mouse liver, showing their functional role in urea cycle regulation and ammonia metabolism through SIRT5.

Quantification of metabolic activity from isotope tracing data using automated methodology

This study develops an automated method to quantify metabolic activity from isotope tracing data, revealing reprogrammed mitochondria-cytosol exchange cycles in tumor tissue.

Histone malonylation is regulated by SIRT5 and KAT2A

The paper identifies SIRT5 and KAT2A as regulators of histone malonylation, showing its role in ribosomal gene expression and age-related changes in mouse brains.

Metabolic adaptations underlie epigenetic vulnerabilities in chemoresistant breast cancer.

This study identifies metabolic adaptations in taxane-resistant triple-negative breast cancer cells that lead to epigenetic vulnerabilities, specifically through altered methionine metabolism and H3K27me3 redistribution.

Acetate is generated de novo from glucose metabolism in mammals and is coupled to central carbon metabolism

The paper shows that glucose metabolism generates acetate through two mechanisms and demonstrates its role in maintaining Ac-CoA pools and cell proliferation under specific metabolic conditions.