Acetate is generated de novo from glucose metabolism in mammals and is coupled to central carbon metabolism
Xiaojing Liu, Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Kathryn E. Wellen, David G. Kirsch, Jason W. Locasale
The paper shows that glucose metabolism generates acetate through two mechanisms and demonstrates its role in maintaining Ac-CoA pools and cell proliferation under specific metabolic conditions.
bioRxiv · Feb 4, 2018 · PreprintBiochemistry