A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation
Bao V. Nguyen, Can Özden, Kairong Dong, Oguz Can Koc, Ana P. Torres‐Ocampo, Noelle Dziedzic, Daniel Flaherty, Jian An Huang, Saketh Sankara, Nikki Lyn Abromson, Diana R. Tomchick, Rafael A. Fissore, Jianhan Chen, Scott C. Garman, Margaret M. Stratton
This study identifies a domain-swapped conformation in CaMKII that enables linker-mediated allosteric regulation, demonstrated through structural, computational, and live-cell analyses.
Nature Communications · Sep 26, 2025Peer-reviewedBiochemistry