Diana R. Tomchick

DancE: A DNA-Activated Bacterial cGAS-like Enzyme in Antiphage Immune Defense

The paper identifies DancE, a bacterial cGAS-like enzyme activated by DNA, and shows its regulation by DnaK and activation by lambda phage protease gpC.

TIR-like NADases act in bacterial immunity and the RNA vault

This study identifies DUF4062 as TIR-like NADases involved in bacterial antiphage defense and eukaryotic RNA vault function through structural and biochemical analyses.

Bacterial ubiquitin ligase engineered for small molecule and protein target identification

This paper introduces SidBait, a modular proximity ligation approach to identify small molecule and protein targets, validated with known interactions and applied to discover new targets like CaMKII and CapZ.

ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathways

This study identifies ACAD10 as encoding two enzymes involved in ether lipid biosynthesis and salvage, linking them to type 2 diabetes risk.

Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.