Multiplexed embryo profiling links cellular state to zygotic genome activation in single cells
Max Hess, Marvin F. Wyss, Edlyn Wu, Gian-Marco Schaniel, Joel Lüthi, Chiara Rebagliati, Daniel Hannuschke, Nadine L. Vastenhouw, Darren T. Gilmour, Shayan Shamipour, Lucas Pelkmans
The paper introduces 3D-4i imaging and analysis to study cell cycle dynamics and transcriptional output during zygotic genome activation in zebrafish embryos.
Nature Communications · Sep 17, 2026Peer-reviewedSystems Biology