Dynamic Changes in Chloride Homeostasis Coordinate Midbrain Inhibitory Network Activity during Reward Learning
Joyce Woo, Ajay R. Uprety, Daniel J. Reid, I. Chang, Aelon Ketema Samuel, Helena de Carvalho Schuch, Caroline C. Swain, Alexey Ostroumov
This study shows that during reward learning, reduced KCC2 in midbrain GABA neurons alters network activity and dopamine responses, essential for forming new reward associations.
Nature Communications · Dec 9, 2025Peer-reviewedNeuroscience