Targeting IL-1/IRAK1/4 signaling in Acute Myeloid Leukemia Stem Cells Following Treatment and Relapse
Tzu‐Chieh Ho, Mark W. LaMere, Hiroki Kawano, Daniel K. Byun, Elizabeth A. LaMere, Yu‐Chiao Chiu, Chunmo Chen, Li‐Ju Wang, Jian Wang, Baskar Ramdas, Nikolay V. Dokholyan, Laura Maria Calvi, Jane L. Liesveld, Craig T. Jordan, Rakesh K. Singh, , Michael W. Becker
This study identifies IL-1/IRAK1/4 signaling as a therapeutic target in AML stem cells, showing that UR241-2 inhibits LSC clonogenicity and engraftment in both diagnosis and relapse.
Leukemia · Dec 19, 2025Peer-reviewedCancer Biology