Craig T. Jordan

This study identifies metabolic vulnerabilities in Down syndrome B-cell acute lymphoblastic leukemia and shows that Venetoclax effectively targets these vulnerabilities.

This study identifies NAMPT as a metabolic vulnerability in HR-MDS HSPCs, showing its inhibition reduces their survival and disease burden.

This study identifies IL-1/IRAK1/4 signaling as a therapeutic target in AML stem cells, showing that UR241-2 inhibits LSC clonogenicity and engraftment in both diagnosis and relapse.

This study develops an efficient siRNA transfection method for primary human leukemia stem and progenitor cells, enabling effective gene knockdown and biological activity assessment.

scExploreR provides a user-friendly platform for non-programmers to analyze multimodal single-cell data with customizable plots and seamless handling of different input formats.

This study identifies IRF2BP2 cytoplasmic sequestration by MCL1 as a mechanism driving venetoclax and azacitidine resistance in AML through ACSL1 derepression.

This study identifies the taurine-taurine transporter axis as a critical regulator of myeloid leukemia using temporal single-cell RNA-sequencing and functional experiments.

This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.

The paper introduces scraps, a pipeline for high-resolution APA detection in scRNA-seq, showing it outperforms existing methods and enables assessment of internal priming events.