Cancer BiologyLeukemiaPeer-reviewed
Targeting IL-1/IRAK1/4 signaling in Acute Myeloid Leukemia Stem Cells Following Treatment and Relapse
Tzu‐Chieh Ho, Mark W. LaMere, Hiroki Kawano…·Michael W. Becker
This study identifies IL-1/IRAK1/4 signaling as a therapeutic target in AML stem cells, showing that UR241-2 inhibits LSC clonogenicity and engraftment in both diagnosis and relapse.
4 citations