PDE4 Inhibitor Apremilast Rebalances Inflammatory Responses to Pseudomonas aeruginosa Infection in CF Rats
Linto Antony, Lawrence W. Rasmussen, Denise D. Stanford, Antonio Demarcus Allen, Daniel Kennedy, Levi Brewer, Aditi Shanbhag, Jennifer R. LaFontaine, Sammeta Vamsee Raju
This study evaluates apremilast's ability to modulate inflammation in CF rats infected with Pseudomonas aeruginosa, showing preserved lung function and reduced injury without increasing bacterial burden.
bioRxiv · Feb 10, 2026 · PreprintImmunology