HIV reservoirs are dominated by genetically younger and clonally enriched proviruses
Natalie N. Kinloch, Aniqa Shahid, Winnie W. Y. Dong, Don Kirkby, Bradley R. Jones, Charlotte Johanna Beelen, Daniel MacMillan, Guinevere Q. Lee, Talia M. Mota, Hanwei Sudderuddin, Evan Barad, Marianne Harris, Chanson J. Brumme, Richard Brad Jones, Mark A. Brockman, , Zabrina L. Brumme
This study identifies that HIV reservoirs consist mainly of genetically younger, clonally enriched proviruses from the pre-ART period, with defective proviruses persisting longer.
mBio · Nov 16, 2023Peer-reviewedGenetics