Author

Marianne Harris

University of British ColumbiaORCID 0000-0002-8016-9177Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Aniqa ShahidiD· 2 shared Chanson J. BrummeiD· 2 shared Don Kirkby· 2 shared Guinevere Q. LeeiD· 2 shared Natalie N. KinlochiD· 2 shared Richard Brad JonesiD· 2 shared Talia M. MotaiD· 2 shared Winnie W. Y. DongiD· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Aniqa ShahidORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

HIV reservoirs are dominated by genetically younger and clonally enriched proviruses

Natalie N. Kinloch, Aniqa Shahid, Winnie W. Y. Dong, Don Kirkby, Bradley R. Jones, Charlotte Johanna Beelen, Daniel MacMillan, Guinevere Q. Lee, Talia M. Mota, Hanwei Sudderuddin, Evan Barad, Marianne Harris, Chanson J. Brumme, Richard Brad Jones, Mark A. Brockman, , Zabrina L. Brumme

This study identifies that HIV reservoirs consist mainly of genetically younger, clonally enriched proviruses from the pre-ART period, with defective proviruses persisting longer.

mBio · Nov 16, 2023Peer-reviewedGenetics

HIV Diversity Considerations in the Application of the Intact Proviral DNA Assay (IPDA)

Natalie N. Kinloch, Yanqin Ren, Winiffer D. Conce Alberto, Winnie W. Y. Dong, Pragya Khadka, Szu-Han Huang, Talia M. Mota, Andrew Wilson, Aniqa Shahid, Don Kirkby, Marianne Harris, Colin M Kovacs, Erika Benko, Mario Ostrowski, Perla M. Del Río Estrada, , Richard Brad Jones

The paper evaluates the Intact Proviral DNA Assay (IPDA) for HIV reservoir quantification, finding that HIV diversity leads to a 28% failure rate and underestimation of reservoir size.

Nature Communications · Jan 8, 2021Peer-reviewedGenetics