Author

Don Kirkby

BC Centre for Excellence in HIV/AIDS

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Aniqa ShahidiD· 3 shared Chanson J. BrummeiD· 3 shared Guinevere Q. LeeiD· 3 shared Natalie N. KinlochiD· 3 shared Richard Brad JonesiD· 3 shared Winnie W. Y. DongiD· 3 shared Zabrina L. BrummeiD· 3 shared Evan Barad· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Aniqa ShahidORCID

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Author profile →

3 papers

Recent·Most cited

HIV superinfection reveals sequential reservoir reactivation and immune-driven rebound dynamics

F. Harrison Omondi, Aniqa Shahid, Natalie N. Kinloch, Winnie W. Y. Dong, Maggie C. Duncan, Fatima Yaseen, Evan Barad, Nadia Moran-Garcia, Amanda Cabral da Silva, Vitaliy Mysak, Don Kirkby, Mario Ostrowski, Rebecca M. Lynch, Chanson J. Brumme, Colin Kovacs, , Zabrina L. Brumme

This paper studies HIV superinfection to show how immune responses shape rebound dynamics and reservoir reactivation during treatment interruption.

Journal of Virology · Jul 10, 2026Peer-reviewedMolecular Biology

HIV reservoirs are dominated by genetically younger and clonally enriched proviruses

Natalie N. Kinloch, Aniqa Shahid, Winnie W. Y. Dong, Don Kirkby, Bradley R. Jones, Charlotte Johanna Beelen, Daniel MacMillan, Guinevere Q. Lee, Talia M. Mota, Hanwei Sudderuddin, Evan Barad, Marianne Harris, Chanson J. Brumme, Richard Brad Jones, Mark A. Brockman, , Zabrina L. Brumme

This study identifies that HIV reservoirs consist mainly of genetically younger, clonally enriched proviruses from the pre-ART period, with defective proviruses persisting longer.

mBio · Nov 16, 2023Peer-reviewedGenetics

HIV Diversity Considerations in the Application of the Intact Proviral DNA Assay (IPDA)

Natalie N. Kinloch, Yanqin Ren, Winiffer D. Conce Alberto, Winnie W. Y. Dong, Pragya Khadka, Szu-Han Huang, Talia M. Mota, Andrew Wilson, Aniqa Shahid, Don Kirkby, Marianne Harris, Colin M Kovacs, Erika Benko, Mario Ostrowski, Perla M. Del Río Estrada, , Richard Brad Jones

The paper evaluates the Intact Proviral DNA Assay (IPDA) for HIV reservoir quantification, finding that HIV diversity leads to a 28% failure rate and underestimation of reservoir size.

Nature Communications · Jan 8, 2021Peer-reviewedGenetics