Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Danielle C. Groves, Rory F. Cunnison, Andrew McMahon, Haitian Fan, Jane L. Sharps, Adrian Deng, J.R. Keown, Ervin Fodor, Nicole C. Robb
This study uses smFRET to analyze SARS-CoV-2 RNA polymerase inhibitors, revealing remdesivir's mechanism involves polymerase stalling and chain termination.
Nucleic Acids Research · Apr 17, 2025Peer-reviewedMicrobiology