Author

Adrian Deng

University of Warwick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:virus· 3 Research Focus:drug response / drug discovery· 2 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Jeremy R KeowniD· 4 shared Nicole C. RobbiD· 4 shared Danielle Groves· 2 shared Rory F. Cunnison· 2 shared Andrew McMahoniD· 1 shared Angus M Spence· 1 shared Benny Zhibin Liang· 1 shared Billy Wai-Lung Ng· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersMicrobiology

Jeremy R KeownORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular and Structural Characterisation of the MERS-Coronavirus Polymerase

Rory F Cunnison, Sonu Subin Philip, Adrian Deng, Danielle Groves, Angus M Spence, Christopher M Coleman, Jeremy R Keown, Nicole C Robb

This study characterizes the MERS-CoV replication-transcription complex and shows its structural similarity to SARS-CoV-2, with cross-species compatibility highlighting evolutionary conservation and virus-specific adaptations.

bioRxiv · Nov 2, 2026 · PreprintMicrobiology

Structural and functional characterisation of the Crimean-Congo Haemorrhagic Fever Virus RNA Dependent RNA Polymerase

Adrian Deng, Rory F. Cunnison, Loïc Carrique, Franziska Günl, Els Pardon, Jan Steyaert, David Nguyen Duc, Jonathan M. Grimes, Nicole C. Robb, J.R. Keown

This study characterizes the structure and function of CCHFV RNA-dependent RNA polymerase, revealing its unique features and antiviral susceptibility.

Nature Communications · Jun 9, 2026Peer-reviewedMicrobiology

Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET

Danielle C. Groves, Rory F. Cunnison, Andrew McMahon, Haitian Fan, Jane L. Sharps, Adrian Deng, J.R. Keown, Ervin Fodor, Nicole C. Robb

This study uses smFRET to analyze SARS-CoV-2 RNA polymerase inhibitors, revealing remdesivir's mechanism involves polymerase stalling and chain termination.

Nucleic Acids Research · Apr 17, 2025Peer-reviewedMicrobiology

Nucleobase Methylation Enhances SARS-CoV-2 Chain Terminator Evasion of Exonuclease Proofreading

Lin Yang, Rory Cunnison, Carmen Ka Man Tse, Tiantian Xu, Buyu Zhang, Rick Xinzhou Xu, Benny Zhibin Liang, Xunyu Zhou, Danielle Groves, Adrian Deng, Jeremy R Keown, Daqi Yu, Mingyuan Li, Yuanliang Zhai, Billy Wai-Lung Ng, , Peter Pak‐Hang Cheung

This study identifies 5-methyl-3'-dUTP as a nucleoside analogue that effectively terminates RNA chains and resists SARS-CoV-2 exoribonuclease proofreading.

bioRxiv · Sep 20, 2024 · PreprintMicrobiology