MicrobiologyNucleic Acids ResearchPeer-reviewed
Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET
Danielle C. Groves, Rory F. Cunnison, Andrew McMahon…·Nicole C. Robb
This study uses smFRET to analyze SARS-CoV-2 RNA polymerase inhibitors, revealing remdesivir's mechanism involves polymerase stalling and chain termination.