Sustained exposure to CAR-T cell secretome impairs human Hematopoietic Stem Cell function and is reversible by dual TNFα-IFNγ blockade
Siva Sai Naga Anurag Muddineni, Diana Rasoulouniriana, Amilia Meir, Danielle Geller, Debanjan Singha Roy, Einat Tako, Neta Solomon, Tal Avraham, Yael Raz, Rony Chen, Eric Shifrut, Elad Jacoby, Michael Milyavsky
This study shows that sustained exposure of human HSPCs to CAR-T cell secretome impairs their function, but this effect is reversible with dual TNFα-IFNγ blockade.
bioRxiv · Mar 20, 2026 · PreprintCell Biology