Cell BiologybioRxivPreprint
Sustained exposure to CAR-T cell secretome impairs human Hematopoietic Stem Cell function and is reversible by dual TNFα-IFNγ blockade
Siva Sai Naga Anurag Muddineni, Diana Rasoulouniriana, Amilia Meir…·Michael Milyavsky
This study shows that sustained exposure of human HSPCs to CAR-T cell secretome impairs their function, but this effect is reversible with dual TNFα-IFNγ blockade.
DOI 10.64898/2026.03.17.712280