Modeling Masticatory Myalgia to Headache-like Referred Pain Triggers Local Gene Plasticity at Referred Pain Sites
Anahit H. Hovhannisyan, Jessica Aldape, Jennifer M. Mecklenburg, Jessie J. Alfaro, Yi Zou, Zhao Lai, Wei Guo, Jiale Yang, Malin M Ernberg, Danilo Boada, Ke Ren, Armen N. Akopian
This study models referred pain in mice by stimulating masticatory muscles and finds that TM stimulation induces longer-lasting headache-like behavior and gene plasticity in referred sites.
bioRxiv · Mar 26, 2025 · PreprintNeuroscience