Armen N. Akopian

The paper examines PRLR isoform expression in human dorsal root ganglia, finding higher PRLR-L (ΔS1) expression in females and reduced expression in females with chronic pain.

The paper investigates T-cell distribution in the dorsal root ganglion across species, sex, and age, finding similar levels in humans, non-human primates, and pigs, but fewer in rats and absent in mice, with sex and age differences in humans.

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

This study identifies sensory fiber types in mouse TMJ tissues using immunohistochemistry, finding peptidergic fibers dominate with minimal non-peptidergic nociceptors.

This study examines sensory and sympathetic nerve profiles in retrodiscal tissues of TMJD patients, finding reduced sensory nerve density in condylar hyperplasia compared to other subtypes.

The paper characterizes mechanically activated currents in trigeminal neurons of non-human primates, identifying distinct neuronal subtypes and their functional properties.

This study models referred pain in mice by stimulating masticatory muscles and finds that TM stimulation induces longer-lasting headache-like behavior and gene plasticity in referred sites.

This study examines gene expression changes in male and female mice following paclitaxel-induced neuropathy, finding sex-dependent gene plasticity linked to tissue regeneration and degeneration.

This study examines sensory nerve types innervating masticatory muscles in common marmosets, finding distinct innervation patterns with differences in fiber types across muscle groups.

This study profiles non-neuronal and immune cells in mouse trigeminal ganglia using scRNA-seq, FC, and IHC, identifying and classifying cell types based on gene expression and markers.

This study investigates how inflammation and tissue damage in masseter muscle relate to the resolution of chronic myalgia using CFA and collagenase-induced models.

The paper performs transcriptomic analysis of human dental biopsies to identify gene expression differences between symptomatic and asymptomatic patients and between sexes.

The paper investigates FMRP expression in human nociceptor axons of the spinal dorsal horn, finding it colocalizes with pain-related markers and suggests a role in sex dimorphic chronic pain mechanisms.

This study investigates the sex-specific role of CGRP in pain models, finding that CGRP promotes pain plasticity in female mice but has limited impact in males.

This study identifies the MrgprB2/MrgprX2 receptor axis as a key regulator of alcohol withdrawal-induced headache through mast cell degranulation and CRF signaling.

The paper identifies sex differences in nociceptor translatomes, revealing sex-specific prostaglandin signaling differences in male and female mice.

This study identifies sex-specific neuroendocrine mechanisms in chronic pain, showing that prolactin receptor signaling in sensory neurons contributes to hyperalgesic priming in females but not males.

This study identifies a specific subset of sensory neurons expressing PAR2 that mediate mechanical and affective pain behaviors, clarifying the cellular basis of PAR2-evoked pain.

The paper analyzes human tibial nerve transcriptomes to identify sex-dimorphic gene expression related to pain, inflammation, and neuro-immunity.