Wei Guo

Small extracellular vesicles mediate the antihyperalgesic effect of bone marrow stromal cells: the role of "priming"

This study shows that bone marrow stromal cell-derived small extracellular vesicles reduce neuropathic pain in mice, with their efficacy enhanced by prior exposure to injury conditions.

Novel combination of irreversible electroporation and allogenic chimeric antigen receptor (CAR) T-cell therapy synergizes therapeutic outcomes in a preclinical human pancreatic cancer mouse model

This study combines irreversible electroporation with CAR T-cell therapy to improve outcomes in a pancreatic cancer mouse model by targeting residual tumor cells post-ablation.

CART-GPT: A T Cell-Informed AI Linguistic Framework for Interpreting Neurotoxicity and Therapeutic Outcomes in CAR-T Therapy

CART-GPT predicts CAR-T therapy efficacy and neurotoxicity risk using a transformer model trained on 1.12 million single-cell RNA-seq profiles with clinical outcomes.

Modeling Masticatory Myalgia to Headache-like Referred Pain Triggers Local Gene Plasticity at Referred Pain Sites

This study models referred pain in mice by stimulating masticatory muscles and finds that TM stimulation induces longer-lasting headache-like behavior and gene plasticity in referred sites.