Zhao Lai

This study identifies four coordinated transcriptional programs in Chlamydia trachomatis during its developmental cycle using time-course RNA sequencing.

This study shows that an attenuated Mycobacterium tuberculosis vaccine induces bronchus-associated lymphoid tissue (iBALT) and protects against heterologous TB challenge in macaques.

This study identifies midkine (MDK) as a critical regulator of medulloblastoma growth and survival, showing that its suppression reduces tumor growth and prolongs survival in xenograft models.

This study identifies diverse mechanisms of SMARCB1 inactivation and genome maintenance defects in malignant rhabdoid tumors through multi-omics profiling of patient-derived models.

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

The paper investigates how hybridization affects gene expression in brain tissues by identifying cell type-specific regulatory variation in interspecies fish hybrids.

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

This study identifies sensory fiber types in mouse TMJ tissues using immunohistochemistry, finding peptidergic fibers dominate with minimal non-peptidergic nociceptors.

This study models referred pain in mice by stimulating masticatory muscles and finds that TM stimulation induces longer-lasting headache-like behavior and gene plasticity in referred sites.

The paper identifies a locus in one Xiphophorus species that represses an oncogene from another species, providing insights into hybrid incompatibility and pigment cell regulation.

This study examines gene expression changes in male and female mice following paclitaxel-induced neuropathy, finding sex-dependent gene plasticity linked to tissue regeneration and degeneration.

This study profiles non-neuronal and immune cells in mouse trigeminal ganglia using scRNA-seq, FC, and IHC, identifying and classifying cell types based on gene expression and markers.

Spatial-Live provides a lightweight tool for visualizing single-cell spatial-omics data in 3D with interactive features and data integration.

The paper identifies sex-dependent differences in transcriptomic profiles of lingual sensory neurons in naive and tongue-tumor bearing mice.

This study investigates how inflammation and tissue damage in masseter muscle relate to the resolution of chronic myalgia using CFA and collagenase-induced models.

The paper performs transcriptomic analysis of human dental biopsies to identify gene expression differences between symptomatic and asymptomatic patients and between sexes.

This paper shows that GrgA regulates Chlamydia trachomatis growth and development by controlling transcription factors Euo and HrcA, and a virulence factor PmpI.

This paper designs an ancestry informative marker panel using whole exome sequencing data to estimate genetic ancestry in Hispanic populations, achieving high accuracy in admixture proportion estimation.

This paper introduces XBSeq, a differential expression analysis algorithm for RNA-seq data that accounts for non-exonic mapped reads, showing improved performance in noisy conditions.