Quantitative profiling of human translation initiation reveals regulatory elements that potently affect endogenous and therapeutically modified mRNAs
Cole J.T. Lewis, Li Xie, Shivani Bhandarkar, Danni Jin, Kyrillos Abdallah, Austin S. Draycott, Yixuan Chen, Carson C. Thoreen, Wendy V. Gilbert
The paper quantifies translation initiation on human mRNAs, identifies regulatory elements with potent effects, and shows that N1-methylpseudouridine enhances translation in specific 5' UTRs.
bioRxiv · Feb 28, 2024 · PreprintSystems Biology