Author

Yixuan Chen

University of VirginiaORCID 0000-0002-4879-7165Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam W. TurneriD· 1 shared Ani W ManichaikuliD· 1 shared Austin S. DraycottiD· 1 shared Carson C. ThoreeniD· 1 shared Chaojie YangiD· 1 shared Christian Lacks Lino CardenasiD· 1 shared Clint L. MilleriD· 1 shared Cole J.T. LewisiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Adam W. TurnerORCID

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2 papers

Recent·Most cited

Quantitative profiling of human translation initiation reveals regulatory elements that potently affect endogenous and therapeutically modified mRNAs

Cole J.T. Lewis, Li Xie, Shivani Bhandarkar, Danni Jin, Kyrillos Abdallah, Austin S. Draycott, Yixuan Chen, Carson C. Thoreen, Wendy V. Gilbert

The paper quantifies translation initiation on human mRNAs, identifies regulatory elements with potent effects, and shows that N1-methylpseudouridine enhances translation in specific 5' UTRs.

bioRxiv · Feb 28, 2024 · PreprintSystems Biology

FHL5 controls vascular disease-associated gene programs in smooth muscle cells

Doris Wong, Gaelle E Auguste, Christian Lacks Lino Cardenas, Adam W. Turner, Yixuan Chen, Yipei Song, Lijiang Ma, R. Noah Perry, Rédouane Aherrahrou, Maniselvan Kuppusamy, Chaojie Yang, José Verdezoto Mosquera, Collin Dube, Mohammad Daud Khan, Meredith Palmore, , Clint L. Miller

This study identifies FHL5 as a causal gene for vascular disease risk through eQTL colocalization and functional analyses, showing its role in vascular remodeling and calcification.

Circulation Research · Apr 5, 2023Peer-reviewedGenomics