Author

Carson C. Thoreen

Yale UniversityORCID 0000-0003-1164-7224Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Assay:metagenomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Maegan J. Watson· 2 shared Antonia M. G. van den ElzeniD· 1 shared Austin S. DraycottiD· 1 shared Cole J.T. LewisiD· 1 shared Danni Jin· 1 shared Kyrillos AbdallahiD· 1 shared Li XieiD· 1 shared Mark S. Williams· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersNeuroscience

Maegan J. Watson

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 9, 2025

Larp1 supports brain growth and spatial memory via post-transcriptional control of the translation machinery

Mark S. Williams, Maegan J. Watson, Carson C. Thoreen

This study shows that Larp1 is essential for brain growth and spatial memory by regulating the translation of TOP mRNAs.

DOI 10.1101/2025.10.09.681478

mouseexperimental assay

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Systems BiologybioRxivPreprintFeb 28, 2024

Quantitative profiling of human translation initiation reveals regulatory elements that potently affect endogenous and therapeutically modified mRNAs

Cole J.T. Lewis, Li Xie, Shivani Bhandarkar…·Wendy V. Gilbert

The paper quantifies translation initiation on human mRNAs, identifies regulatory elements with potent effects, and shows that N1-methylpseudouridine enhances translation in specific 5' UTRs.

5 citations

humanmetagenomics

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GeneticsPLoS GeneticsPeer-reviewedNov 28, 2022

mRNA 5' terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay

Antonia M. G. van den Elzen, Maegan J. Watson, Carson C. Thoreen

The paper identifies how 5' terminal sequences of mRNAs influence expression levels by affecting transcription, translation, and decay, revealing two classes of sequences with distinct regulatory profiles.

12 citations

humanbulk RNA-seq

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