Specialized axon initial segment enables low firing threshold and rapid action potential output in fast-spiking interneurons of the human neocortex
Emőke Bakos, Ádám Tiszlavicz, Viktor Szegedi, Abdennour Douida, Szabina Furdan, Daphne K. Welter, Jonathan J. M. Landry, Balázs Bende, Gábor Hutóczki, Pál Barzó, Gábor Tamás, Vladimı́r Beneš, Attila László Szűcs, Karri P. Lamsa
The paper identifies structural and molecular differences in the axon initial segment of human fast-spiking interneurons that lower firing thresholds and reduce input-output delay compared to mice.
bioRxiv · Oct 28, 2024 · PreprintNeuroscience