Abdennour Douida

This study shows that Kir potassium channels regulate input excitability in parvalbumin interneurons similarly in human and mouse, inhibiting them during postsynaptic potentials.

The paper identifies structural and molecular differences in the axon initial segment of human fast-spiking interneurons that lower firing thresholds and reduce input-output delay compared to mice.

The paper investigates age-related changes in fast-spiking interneurons in the human neocortex and finds a significant weakening of action potential characteristics with age.