Gábor Tamás

Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum

The paper analyzes multi-modal Patch-seq data from macaque striatum to reveal morphoelectric diversity and functional specialization of neuronal cell types, highlighting primate-specific features and differences from rodents.

Regulation of input excitability in human and mouse parvalbumin interneurons by Kir potassium channels

This study shows that Kir potassium channels regulate input excitability in parvalbumin interneurons similarly in human and mouse, inhibiting them during postsynaptic potentials.

Accelerated signal propagation speed in human neocortical dendrites

The paper identifies faster signal propagation in human neocortical dendrites compared to rodents, attributed to larger dendritic structures and conductance properties.

Specialized axon initial segment enables low firing threshold and rapid action potential output in fast-spiking interneurons of the human neocortex

The paper identifies structural and molecular differences in the axon initial segment of human fast-spiking interneurons that lower firing thresholds and reduce input-output delay compared to mice.

Electrophysiology and Morphology of Human Cortical Supragranular Pyramidal Cells in a Wide Age Range

This study examines age-related changes in the electrophysiological and morphological properties of human cortical supragranular pyramidal cells across a wide age range.

Aging-associated weakening of the action potential in fast-spiking interneurons in the human neocortex

The paper investigates age-related changes in fast-spiking interneurons in the human neocortex and finds a significant weakening of action potential characteristics with age.

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

The paper identifies transcriptomic and morpho-electric diversity in human neocortical layer 1 interneurons, revealing greater subclass distinction compared to mouse.

Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex

The paper reports spontaneously occurring retroaxonal action potentials in interneurons that are independent of network inputs, showing distinct temporal contributions to network activity compared to AIS-APs.

Differential effects of group III metabotropic glutamate receptors on spontaneous inhibitory synaptic currents in spine-innervating double bouquet and parvalbumin-expressing dendrite-targeting GABAergic interneurons in human neocortex

The paper investigates how group III mGluR activation affects GABAergic synaptic transmission in two types of human neocortical interneurons, finding differential effects on inhibitory currents.

Linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

The paper shows that metabotropic GABAB responses sum linearly while ionotropic GABAA responses sum sublinearly in neurogliaform interneurons.

Somatic HCN channels augment and speed up GABAergic basket cell input-output function in human neocortex

The paper identifies a unique somatic leak current mechanism in human GABAergic basket cells that enhances signal transmission fidelity and speed compared to rodent counterparts.

Systemic administration of Ivabradine, an HCN channel inhibitor, blocks spontaneous absence seizures

This study shows that systemic ivabradine, an HCN channel inhibitor, reduces absence seizures in rats, suggesting its potential as a new treatment for this condition.

Automatic deep learning driven label-free image guided patch clamp system for human and rodent in vitro slice physiology

The paper develops an automated patch clamp system using deep learning and image analysis to measure neurons in human and rodent brain slices.

Non-linear Computation Between Neighboring Dendritic Hotspots in Rat CA1 Hippocampal Interneurons

The paper investigates how dendritic hotspots in rat CA1 interneurons integrate signals non-linearly, showing supralinear Ca2+ responses and sublinear EPSPs at different spatial distances.

Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex

The paper investigates GABAergic autapses in parvalbumin-expressing basket cells across human and mouse neocortex, finding robust self-innervation in pvBCs but not in other interneurons.

Microglia monitor and protect neuronal function via specialized somatic purinergic junctions

The paper identifies specialized somatic microglia-neuron junctions that enable microglia to monitor and protect neuronal function through purinergic signaling.

Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type

The paper identifies a novel human cortical GABAergic interneuron subtype with unique transcriptomic, morphological, and physiological features not observed in rodents.