Author

Dara E. Leto

Denali Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adreesh MukherjeeiD· 1 shared Akshi BassiiD· 1 shared Anastasia G. HenryiD· 1 shared Anbu Kayalvizhi· 1 shared Andrew S. PetersoniD· 1 shared Atanu BiswasiD· 1 shared Charugulla SandeepiD· 1 shared Christopher P. Walczak· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Adreesh MukherjeeORCID

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Author profile →

2 papers

Recent·Most cited

The genetic drivers of juvenile, young, and early-onset Parkinson's Disease in India

Shan V. Andrews, Prashanth Lingappa Kukkle, Ramesh Menon, Thenral S. Geetha, Vinay Goyal, Rukmini Mridula Kandadai, Hrishikesh Kumar, Rupam Borgohain, Adreesh Mukherjee, Pettarusp Murzban Wadia, Ravi Yadav, Soaham Desai, Niraj Kumar, Deepika Joshi, Sakthivel Murugan, , Vedam Lakshmi Ramprasad

This study identifies genetic risk factors for early-onset Parkinson's Disease in a South Asian population, finding a genome-wide significant signal in the SNCA region and associations with BSN gene variants.

Movement Disorders · Nov 28, 2023Peer-reviewedGenetic & Genomic Medicine

Parallel genome-wide CRISPR analysis identifies a role for heterotypic ubiquitin chains in ER-associated degradation

Dara E. Leto, David W. Morgens, Lichao Zhang, Christopher P. Walczak, Joshua E. Elias, Michael C. Bassik, Ron R. Kopito

The paper uses CRISPR screening to identify cytosolic ubiquitin conjugating machinery involved in ERAD by analyzing substrate-specific ubiquitin chain conjugation.

bioRxiv · Jun 17, 2018 · PreprintCell Biology