The paper establishes and validates an iPSC line from an Eastern Indian donor, providing a population-specific control resource for disease modelling.

bioRxiv · Jun 10, 2026 · PreprintCell Biology

Development of a Stable Human iPSC Line from Peripheral Blood: A Control Resource for Disease Modeling

Surajit Malakar, Vasanth Thamodaran, Tamali Halder, Deepika Joshi, Parimal Kumar Das

The paper describes the generation and characterization of a stable human iPSC line from peripheral blood to serve as a control resource for disease modeling and regenerative medicine.

bioRxiv · Aug 21, 2025 · PreprintMolecular Biology

Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation

Larissa Jank, Saumitra Sen Singh, Judy J. Lee, Asmita Dhukhwa, Fatemeh Siavoshi, Deepika Joshi, Veronica Minney, Kanak Gupta, Sudeep Ghimire, Pragney Deme, Vinícius Andreoli Schoeps, Karthik Soman, Dimitrios C. Ladakis, Matthew D. Smith, Kamil Borkowski, , Pavan Bhargava

The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.

bioRxiv · Oct 27, 2024 · PreprintNeuroscience

The genetic drivers of juvenile, young, and early-onset Parkinson's Disease in India

Shan V. Andrews, Prashanth Lingappa Kukkle, Ramesh Menon, Thenral S. Geetha, Vinay Goyal, Rukmini Mridula Kandadai, Hrishikesh Kumar, Rupam Borgohain, Adreesh Mukherjee, Pettarusp Murzban Wadia, Ravi Yadav, Soaham Desai, Niraj Kumar, Deepika Joshi, Sakthivel Murugan, , Vedam Lakshmi Ramprasad

This study identifies genetic risk factors for early-onset Parkinson's Disease in a South Asian population, finding a genome-wide significant signal in the SNCA region and associations with BSN gene variants.

Movement Disorders · Nov 28, 2023Peer-reviewedGenetic & Genomic Medicine