Parallel genome-wide CRISPR analysis identifies a role for heterotypic ubiquitin chains in ER-associated degradation
Dara E. Leto, David W. Morgens, Lichao Zhang, Christopher P. Walczak, Joshua E. Elias, Michael C. Bassik, Ron R. Kopito
The paper uses CRISPR screening to identify cytosolic ubiquitin conjugating machinery involved in ERAD by analyzing substrate-specific ubiquitin chain conjugation.
bioRxiv · Jun 17, 2018 · PreprintCell Biology