Vascular Destabilization and Pericyte Detachment are Mediated by hIAPP Aggregation in Transgenic Mice.
J. P. Koepke, Luciana Mateus Gonçalves, Catarina de Andrade Barboza, Alfred C. Aplin, Daryl J. Hackney, S. Gharib, Olivia G. Mohn, Melody Teng, Joseph Castillo, Joana Almaça, Rebecca L. Hull-Meichle
This study shows hIAPP aggregation disrupts islet microvascular stability by downregulating EC genes and causing pericyte detachment, impairing vasomotor responses.
bioRxiv · Feb 22, 2026 · PreprintMolecular Biology