Author

J. P. Koepke

University of Alberta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:electrophysiology· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alfred C. ApliniD· 1 shared Andrew G. EdwardsiD· 1 shared Catarina de Andrade BarbozaiD· 1 shared Daryl J. Hackney· 1 shared Ishan GoswamiiD· 1 shared Joana AlmaçaiD· 1 shared Joseph CastilloiD· 1 shared Luciana Mateus GonçalvesiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Alfred C. AplinORCID

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2 papers

Recent·Most cited

Computational modelling of natural cell-to-cell heterogeneity reveals key parameters that control the diversity of human pancreatic islet β-cell excitability in response to glucose

Ishan Goswami, J. P. Koepke, Masoud Baghelani, Patrick E. MacDonald, Vira V. Kravets, Peter E. Light, Andrew G. Edwards

The paper uses computational modeling to identify key parameters controlling glucose-induced excitability diversity in human pancreatic β-cells.

bioRxiv · Mar 2, 2026 · PreprintPhysiology

Vascular Destabilization and Pericyte Detachment are Mediated by hIAPP Aggregation in Transgenic Mice.

J. P. Koepke, Luciana Mateus Gonçalves, Catarina de Andrade Barboza, Alfred C. Aplin, Daryl J. Hackney, S. Gharib, Olivia G. Mohn, Melody Teng, Joseph Castillo, Joana Almaça, Rebecca L. Hull-Meichle

This study shows hIAPP aggregation disrupts islet microvascular stability by downregulating EC genes and causing pericyte detachment, impairing vasomotor responses.

bioRxiv · Feb 22, 2026 · PreprintMolecular Biology