Author

Alfred C. Aplin

United States Department of Veterans AffairsORCID 0000-0002-3346-9484Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Catarina de Andrade BarbozaiD· 1 shared Daryl J. Hackney· 1 shared J. P. Koepke· 1 shared Joana AlmaçaiD· 1 shared Joseph CastilloiD· 1 shared Luciana Mateus GonçalvesiD· 1 shared Melody Teng· 1 shared Olivia G. Mohn· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Catarina de Andrade BarbozaORCID

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1 paper

Recent·Most cited

Vascular Destabilization and Pericyte Detachment are Mediated by hIAPP Aggregation in Transgenic Mice.

J. P. Koepke, Luciana Mateus Gonçalves, Catarina de Andrade Barboza, Alfred C. Aplin, Daryl J. Hackney, S. Gharib, Olivia G. Mohn, Melody Teng, Joseph Castillo, Joana Almaça, Rebecca L. Hull-Meichle

This study shows hIAPP aggregation disrupts islet microvascular stability by downregulating EC genes and causing pericyte detachment, impairing vasomotor responses.

bioRxiv · Feb 22, 2026 · PreprintMolecular Biology