Calcium-Activated Sarcomere Contractility Drives Cardiomyocyte Maturation and the Response to External Mechanical Cues but is Dispensable for Sarcomere Formation
Laura A. Sherer, Abigail Nagle, Mary Papadaki, Seby Louis Edassery, Dasom Yoo, Lauren D’Amico, Daniel Brambila-Diaz, Michael Regnier, Jonathan A. Kirk
This study shows calcium-activated contractility is not needed for sarcomere formation but is essential for cardiomyocyte maturation and response to mechanical cues, with nanopatterns aiding maturation in non-contractile cells.
bioRxiv · Mar 18, 2025 · PreprintBioengineering