Age-Dependent Fibroblast Programs Govern Regenerative and Fibrotic Tendon Repair
Ahmet Engin Pazarçeviren, Minoo Bastani, Dean Roell, Julia Sheyn, Dave Huang, Oksana Shelest, Mia Orr, Lea Zila, Melodie F. Metzger, Wafa Tawackoli, Dmitriy Sheyn
This study identifies age-dependent fibroblast programs in tendon repair, showing young rats exhibit more fibrotic healing due to sustained Nox4-Gas6 pathways.
bioRxiv · Jul 26, 2026 · PreprintDevelopmental Biology