Oksana Shelest

This study develops iPSC-derived anti-inflammatory macrophages to treat post-traumatic osteoarthritis, showing they reduce inflammation and improve joint outcomes in preclinical models.

This study identifies age-dependent fibroblast programs in tendon repair, showing young rats exhibit more fibrotic healing due to sustained Nox4-Gas6 pathways.

This study creates a lifespan snRNA-seq atlas of mouse spinal cord, revealing how aging and SOD1-G93A ALS interact regionally and cell-type specifically.

This study identifies lesion-remote astrocytes (LRAs) that drive microglia-mediated white matter repair after spinal cord injury through Ccn1-dependent mechanisms.

This study examines sex-dependent and anatomic differences in motor function decline in SOD1G93A mice, finding males show earlier and less localized onset, and distinct decline rates between sexes.

The paper identifies a stress-induced subtype of nucleus pulposus cells in degenerating intervertebral discs that trigger discogenic low back pain.

This study shows that juvenile AAV9-MCT8 gene therapy improves neurological and behavioral deficits in an AHDS mouse model by restoring TH levels and gene expression.