Dmitriy Sheyn

Large oncosomes reprogram bone marrow mesenchymal stem cells to establish a pre-metastatic niche

This study shows that large oncosomes reprogram bone marrow mesenchymal stem cells to create a pre-metastatic niche by inducing an interferon-driven inflammatory response.

Tendon-derived injectable bio-instructive gel augments tenogenic differentiation of iMSC-SCX cells and extracellular matrix remodeling

This study develops a porcine tendon-derived hydrogel to enhance tenogenic differentiation and extracellular matrix remodeling of iMSC-SCX cells in a rat tendon injury model.

Modulating Inflammation in Post-Traumatic Osteoarthritis using iPSC-derived Anti-inflammatory Macrophages

This study develops iPSC-derived anti-inflammatory macrophages to treat post-traumatic osteoarthritis, showing they reduce inflammation and improve joint outcomes in preclinical models.

Age-Dependent Fibroblast Programs Govern Regenerative and Fibrotic Tendon Repair

This study identifies age-dependent fibroblast programs in tendon repair, showing young rats exhibit more fibrotic healing due to sustained Nox4-Gas6 pathways.

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain via Notochordal Cell Loss and Pain-inducing Nucleus Pulposus Cell Emergence

This study develops a porcine model of intervertebral disc injury that mimics human discogenic pain through notochordal cell loss and nucleus pulposus cell emergence, validated by MRI, biobehavioral testing, and single-cell transcriptomics.

Single Cell Transcriptomics-informed Induced Pluripotent Stem Cells Differentiation to Tenogenic Lineage

This study differentiates human iPSCs to the syndetome stage using chemically defined media and small molecules informed by single-cell RNA-sequencing, revealing Wnt pathway involvement in off-target neural differentiation and improved syndetome induction with a WNT inhibitor.

Environmentally stressed human nucleus pulposus cells trigger the onset of discogenic low back pain

The paper identifies a stress-induced subtype of nucleus pulposus cells in degenerating intervertebral discs that trigger discogenic low back pain.

Single-cell Atlas Unveils Cellular Heterogeneity and Novel Markers in Human Neonatal and Adult Intervertebral Discs

The paper generates and compares single-cell atlases of human neonatal and adult intervertebral discs to identify cellular heterogeneity, sub-populations, and developmental trajectories.