Author

Julia Sheyn

Cedars-Sinai Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 3 Cell Biology· 2 Neuroscience· 2 Molecular Biology· 1

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Research Focus:cell type annotation· 6 Approach:statistical model· 6 Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 3 Assay:proteomics· 3 Research Focus:cell-cell communication· 2

Frequent Co-Authors

Dmitriy SheyniD· 6 shared Melissa Chavez· 4 shared Wafa TawackoliiD· 4 shared Minoo Bastani· 3 shared Oksana ShelestiD· 3 shared Ahmet Engin PazarçevireniD· 2 shared Altan RentsendorjiD· 2 shared Chloe M. CastanedaiD· 2 shared

Activity by Year

2023-2026 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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6 shared papersDevelopmental Biology

Dmitriy SheynORCID

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Tendon-derived injectable bio-instructive gel augments tenogenic differentiation of iMSC-SCX cells and extracellular matrix remodeling

Ahmet Engin Pazarçeviren, Hyeongseop Keum, Léo‐Paul Tricou, Minoo Bastani, Melissa Chavez, Julia Sheyn, Gaia Dupont, Myung‐Seo Kim, Wafa Tawackoli, Benjamin R. Freedman, Dmitriy Sheyn

This study develops a porcine tendon-derived hydrogel to enhance tenogenic differentiation and extracellular matrix remodeling of iMSC-SCX cells in a rat tendon injury model.

bioRxiv · Sep 3, 2026 · PreprintCell Biology

Modulating Inflammation in Post-Traumatic Osteoarthritis using iPSC-derived Anti-inflammatory Macrophages

Nadia Mahmoudi, Lea Zila, Julia Sheyn, Namdev More, Melissa Chavez, Dean Roell, Rachel LevGur, Anoushka Prasad, Sarah Mohyeddinipour, Mia Orr, Minoo Bastani, Oksana Shelest, Sean Rajaee, Andrew I. Spitzer, Wafa Tawackoli, Dmitriy Sheyn

This study develops iPSC-derived anti-inflammatory macrophages to treat post-traumatic osteoarthritis, showing they reduce inflammation and improve joint outcomes in preclinical models.

bioRxiv · Aug 18, 2026 · PreprintCell Biology

Age-Dependent Fibroblast Programs Govern Regenerative and Fibrotic Tendon Repair

Ahmet Engin Pazarçeviren, Minoo Bastani, Dean Roell, Julia Sheyn, Dave Huang, Oksana Shelest, Mia Orr, Lea Zila, Melodie F. Metzger, Wafa Tawackoli, Dmitriy Sheyn

This study identifies age-dependent fibroblast programs in tendon repair, showing young rats exhibit more fibrotic healing due to sustained Nox4-Gas6 pathways.

bioRxiv · Jul 26, 2026 · PreprintDevelopmental Biology

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain via Notochordal Cell Loss and Pain-inducing Nucleus Pulposus Cell Emergence

Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Debiao Li, Candace L. Floyd, Dmitriy Sheyn

This study develops a porcine model of intervertebral disc injury that mimics human discogenic pain through notochordal cell loss and nucleus pulposus cell emergence, validated by MRI, biobehavioral testing, and single-cell transcriptomics.

JOR Spine · Jul 9, 2026Peer-reviewedDevelopmental Biology

Single Cell Transcriptomics-informed Induced Pluripotent Stem Cells Differentiation to Tenogenic Lineage

Angela Papalamprou, Victoria Yu, Wensen Jiang, Julia Sheyn, Tina Stefanovic, Angel Chen, Chloe M. Castaneda, Melissa Chavez, Dmitriy Sheyn

This study differentiates human iPSCs to the syndetome stage using chemically defined media and small molecules informed by single-cell RNA-sequencing, revealing Wnt pathway involvement in off-target neural differentiation and improved syndetome induction with a WNT inhibitor.

eLife · Apr 24, 2026Peer-reviewedDevelopmental Biology

Synergistic retinal UCHL1 dysregulation and synaptic vulnerability reflect Alzheimer's disease severity

Altan Rentsendorj, Jean‐Philippe Vit, A. Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barrón, Anthony Rodriguez, Bhakta Prasad Gaire, Ousman Jallow, Julia Sheyn, Miyah R. Davis, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, , Maya Koronyo‐Hamaoui

The paper identifies UCHL1 dysregulation and synaptic loss in the retina as markers of Alzheimer's disease severity using integrated multi-omics analysis.

bioRxiv · Feb 5, 2026 · PreprintNeuroscience

Epigenetic derepression of H3K9me3 mitigates Alzheimer-related pathology and improves cognition via immunomodulation and Vgf induction

Dieu-Trang S. Fuchs, Jean‐Philippe Vit, Altan Rentsendorj, Julia Sheyn, Haoshen Shi, Yosef Koronyo, Oksana M. Chepurna, Miyah R. Davis, Jered W. Wilson, Lon S. S. Schneider, Stuart L. Graham, Vivek Gupta, Margaret L. Fahnestock, Tao Sun, Michael T. Kleinman, , Maya Koronyo‐Hamaoui

This study shows that inhibiting H3K9me3 with ETP69 reduces AD pathology and improves cognition by modulating neuroinflammation and inducing Vgf.

bioRxiv · Oct 15, 2024 · PreprintNeuroscience

Environmentally stressed human nucleus pulposus cells trigger the onset of discogenic low back pain

Wensen Jiang, Juliane D. Glaeser, Giselle Kaneda, Julia Sheyn, Jacob T. Wechsler, Stephen R. Stephan, Khosrowdad Salehi, Julie Lynn Chan, Wafa Tawackoli, Pablo Avalos, Christopher N. Johnson, Chloe M. Castaneda, Linda E.A. Kanim, Teerachat Tanasansomboon, Joshua E. Burda, , Dmitriy Sheyn

The paper identifies a stress-induced subtype of nucleus pulposus cells in degenerating intervertebral discs that trigger discogenic low back pain.

bioRxiv · Mar 2, 2023 · PreprintMolecular Biology