Genetic risk of cholangiocarcinoma is linked to the autophagy gene ATG7
Stephanie Greer, Margret Helga Ogmundsdottir, Jiamin Chen, Billy T. Lau, Richard Glenn C. Delacruz, Imelda T. Sandoval, Sigrún Kristjánsdóttir, David A. Jones, Derrick S. Haslem, Robin Romero, Gail Fulde, John Bell, Jon Gunnlaugur Jonasson, Eirı́kur Steingrı́msson, Hanlee P. Ji, Lincoln D. Nadauld
The paper identifies ATG7 as a genetic risk factor for cholangiocarcinoma through germline mutations and population studies, linking autophagy dysfunction to cancer development.
bioRxiv · Nov 22, 2019 · PreprintGenomics