ASC specks and α-synuclein amplify microglial NLRP3 inflammasome activation and co-localize with Lewy body pathology
Karan Thakur, Christine Peladeau, Melissa Hewitt, Klaudia Baumann, David Cai, John Woulfe, Julianna J. Tomlinson, Michael G. Schlossmacher, Jagdeep K. Sandhu
This study shows ASC-Syn assemblies enhance NLRP3 inflammasome activation in microglia and co-localize with Lewy body pathology in human brain tissue.
bioRxiv · Oct 13, 2026 · PreprintNeuroscience