This study shows ASC-Syn assemblies enhance NLRP3 inflammasome activation in microglia and co-localize with Lewy body pathology in human brain tissue.

bioRxiv · Oct 13, 2026 · PreprintNeuroscience

Extracellular vesicles derived from cells overexpressing HGSNAT rescue defects in Mucopolysaccharidosis IIIC neurons

Travis Mooree, Mahsa Taherzadeh, Xuefang Pan, Melissa Hewitt, Caroline Sodja, Dylan Layton‐Matthews, Mehrnaz Fazeli, Anahita Bakhshizadeh, Claudie Charlebois, Marina Rukhlova, Thomas M. Durcan, Anahita Bakhshizadeh Gashti, Seyyed Mehdy Elahi, Jagdeep K. Sandhu, Anna Jezierski, Alexey V. Pshezhetsky

The paper shows that extracellular vesicles from HGSNAT-overexpressing cells can rescue MPS IIIC neuron defects by delivering the enzyme to lysosomes.

bioRxiv · Jul 23, 2026 · PreprintBiochemistry

A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies

Sungwon An, John J. McInnis, Dongin Kim, Yihang Li, Ozge E. Tasdemir-Yilmaz, Jin-Hyung Ahn, Brian C. Mackness, Seung‐Hwan Kwon, Julia Maeve Bonner, Miran Yoo, Simon Dujardin, Donghwan Kim, Jin‐Young Park, Hyesu Yun, Yi Tang, , Can Kayatekin

This paper presents preclinical data on a bispecific antibody, SAR446159, designed to target alpha-synuclein aggregates and cross the blood-brain barrier for treating synucleinopathies.

npj Parkinson s Disease · Aug 22, 2025Peer-reviewedNeuroscience

A hybrid machine learning framework for functional annotation applied to mitochondrial glutathione metabolism and transport in cancers.

Luke S Kennedy, Jagdeep K. Sandhu, Mary‐Ellen Harper, Miroslava Čuperlović‐Culf

The paper develops a hybrid machine learning framework to annotate genes involved in mitochondrial glutathione metabolism and transport in cancers, identifying potential targets and demonstrating high predictive performance.

BMC Bioinformatics · Feb 11, 2025Peer-reviewedBioinformatics