Author

Karan Thakur

University of OttawaORCID 0009-0006-6666-2586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Julianna J. TomlinsoniD· 2 shared Michael G. SchlossmacheriD· 2 shared Alexandre Savard· 1 shared aSCENT-PD Investigators· 1 shared Baptiste LacosteiD· 1 shared Cesar Henrique CominiD· 1 shared Christine Peladeau· 1 shared David Cai· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Julianna J. TomlinsonORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 13, 2026

ASC specks and α-synuclein amplify microglial NLRP3 inflammasome activation and co-localize with Lewy body pathology

Karan Thakur, Christine Peladeau, Melissa Hewitt…·Jagdeep K. Sandhu

This study shows ASC-Syn assemblies enhance NLRP3 inflammasome activation in microglia and co-localize with Lewy body pathology in human brain tissue.

DOI 10.64898/2026.10.02.756339

mousehuman

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NeurosciencebioRxivPreprintJul 31, 2025

Elevated phosphorylated α-synuclein and phosphorylated tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis

Michaela O. Lunn, Karan Thakur, Nathalie A. Lengacher…·Michael G. Schlossmacher

This study shows that Lrrk2 p.G2019S mutant mice exhibit increased phosphorylated α-synuclein and tau in the brain after influenza A infection, suggesting a link between LRRK2 mutations and neurodegeneration.

1 citation

mouseexperimental assay

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Developmental BiologybioRxivPreprintApr 29, 2023

Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation.

Moises Freitas Andrade, Cesar Henrique Comin, Peter C. Van Dyken…·Baptiste Lacoste

This study identifies Hmgb1 in astrocytes as critical for postnatal astrocyte morphogenesis and cerebrovascular maturation, affecting endothelial ultrastructure and neurovascular coupling in adult mice.

1 citation

mousebulk RNA-seq

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