John Woulfe

This study shows ASC-Syn assemblies enhance NLRP3 inflammasome activation in microglia and co-localize with Lewy body pathology in human brain tissue.

This paper studies immune responses in a mouse model of glioblastoma, finding that large tumors induce immune responses at border sites but also generate immunosuppressive necroses that limit therapeutic benefit.

This study identifies IMPDH and PRPS as key enzymes immunoreactive to Reinke crystals in Leydig cells, linking their formation to purine metabolism and potential therapeutic implications.

This study shows TGM2 is involved in efferocytosis by glioblastoma-associated macrophages, promoting immunosuppression and tumor survival.

This study shows that TDP-43 SUMOylation is a stress response that protects neurons, and its disruption is linked to aging and disease.

This paper presents a method to generate olfactory organoids from adult mice to study environmental interactions with the olfactory epithelium and disease processes.

This study examines the relationship between white matter hyperintensities, cortical thickness, and empathy in neurodegenerative and cerebrovascular diseases, finding associations with specific brain regions and demographic factors.

This study investigates how parkin's redox state and insolubility in human midbrain relate to oxidative stress and dopamine metabolism, showing that parkin's cysteine modifications affect H2O2 levels and neuroprotection.

This study identifies oxidative modifications of parkin in adult human brain that confer neuroprotection by reducing H2O2, conjugating dopamine radicals, and forming neuromelanin.