A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision
Julia Vorhauser, Theodoros I. Roumeliotis, David Coupe, Jacky Kieran Leung, Lu Yu, Kristin Böhlig, Thomas Zerjatke, Ingmar Glauche, André Nadler, Jyoti S. Choudhary, Jörg Mansfeld
The paper identifies a redox-sensitive cysteine in p21 that regulates its interaction with CDKs, controlling cell cycle progression and proliferation through a feedback loop.
Molecular Cell · Aug 25, 2025Peer-reviewedCell Biology