FREQUENT GENE CONVERSION IN HUMAN EMBRYOS INDUCED BY DOUBLE STRAND BREAKS
Dan Liang, Nuria Martí Gutiérrez, Tailai Chen, Yeonmi Lee, Sang-Wook Park, Hong Ma, Amy Koski, Riffat Ahmed, Hayley Darby, Ying Li, Crystal Van Dyken, Aleksei E. Mikhalchenko, Thanasup Gonmanee, Tomonari Hayama, Han Zhao, , Shoukhrat M. Mitalipov
This study shows that gene conversion and NHEJ are major DNA repair mechanisms in human embryos, with gene conversion potentially useful for gene correction but also causing extensive loss of heterozygosity.
bioRxiv · Jun 19, 2020 · PreprintGenetics