Hong Ma

Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy

The paper inhibits Elovl1 in a mouse model of ALD to reduce VLCFA accumulation, finding it corrects lipid pathways but also causes unexpected transcriptional changes.

Retinoic acid-dependent loss of synaptic output from bipolar cells impairs visual information processing in inherited retinal degeneration.

The paper shows that retinoic acid receptor inhibition restores synaptic function in bipolar cells of RP models, improving visual signal transmission.

Retinal bipolar cells borrow excitability from amacrine cells to amplify spatial features in dim light

The paper shows that On-cone bipolar cells use NaV channels from coupled amacrine cells to enhance signal transmission in dim light.

Constitutively active STAT5b feminizes mouse liver gene expression

This study shows that constitutively active STAT5b induces female-biased gene expression in male mouse liver, mimicking GH effects, but also causes histopathology at high doses.

FREQUENT GENE CONVERSION IN HUMAN EMBRYOS INDUCED BY DOUBLE STRAND BREAKS

This study shows that gene conversion and NHEJ are major DNA repair mechanisms in human embryos, with gene conversion potentially useful for gene correction but also causing extensive loss of heterozygosity.

Comparative genetic architectures of schizophrenia in East Asian and European populations

This study identifies schizophrenia genetic associations in East Asian and European populations, finding similar genetic effects across ancestries but highlighting challenges in polygenic risk prediction across groups.